comparative anti anaemic activity of murraya koenigii (linn.) spreng leaves and its combination with emblica officinalis in aluminium chloride induced anaemia using rodents.
Purnima A,Vamsee Veena A,Renuka S,Rajendra R
Published in International Journal of Advanced Research in Medical Science
ISSN: xxxx-xxx Impact Factor:xx Volume:1 Issue:1 Year: 12 May,2014 Pages:15-24
Abstract
Murrraya koenigii (curry leaves) and its combination with Emblica officinalis (amla) were evaluated for their antianaemic activity in aluminium chloride induced anaemic animals. Rats were divided into 7 groups of 6 each. Group 1 was given normal saline and served as control and all other groups were given 0.5 mg/kg b.w of AlCl3 for 30 days to induce anaemia. Group 2 served as positive control and Group 3 was treated with synthetic iron (40mg/kg) and served as standard .Group 4 and 5 were treated with different doses (200 and 400 mg/kg b.w.) of aqueous extracts of curry leaves respectively. Whereas Group 6 and 7 were treated with combination of aqueous extract of curry leaves and amla fruit (200 and 400 mg/kg b.w.) respectively. All the treatments were given orally and continued upto 30 days. On 0 and 31 day blood samples were collected by retroorbital puncture and haematological parameters such as haemoglobin (Hb) concentration, RBC count, Mean Haemoglobin Volume (MHV), serum iron, ferritin, and antioxidant parameters such as lipid peroxidation (LPO), superoxide dismutase (SOD) and catalase (CAT) were estimated. Results showed that both curry leaves and its combination with amla showed significant anti anaemic and antioxidant activity but compared to curry leaf extract alone, its combination with amla showed better activity. This may be due to synergistic action of herbs when used in combination and this combination may be an alternative to synthetic iron therapy in anaemia.
Kewords
Aluminum chloride, anaemia, haematological parameters, antioxidant.
Reference
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